Wales v Scotland: Hosts forced into late team change as key man is ruled out
The Welsh Rugby Union said that 77 times-capped Tipuric was sidelined due to tonsillitis, with Scarlets forward James Davies replacing him and Aaron Wainwright taking over from Davies among the substitutes.
Alun Wyn Jones, meanwhile, prepared to set a new world record of 149 Test match appearances.
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Hide AdThe Wales skipper drew level with New Zealand World Cup-winning captain Richie McCaw a week ago, and he led a team looking to end a run of four successive defeats.
Tipuric’s absence meant that Wales head coach Wayne Pivac made seven changes from the side beaten by France last time out.
The switches included a Test debut for Cardiff Blues flanker Shane Lewis-Hughes and starts for the likes of scrum-half Gareth Davies, prop Tomas Francis and lock Will Rowlands, but wing George North was dropped.